Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.
Fiche du document
2012
- doi: 10.1016/j.cell.2012.08.012
- issn: 0092-8674
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2012.08.012
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22939713
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1097-4172
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DD92637F15275
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
PhenotypesCiter ce document
P.A. Andreux et al., « Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits. », Serveur académique Lausannois, ID : 10.1016/j.cell.2012.08.012
Métriques
Partage / Export
Résumé
Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.