Oncogenic Signaling Pathways in The Cancer Genome Atlas.

F. Sanchez-Vega; M. Mina; J. Armenia; W.K. Chatila; A. Luna; K.C. La; S. Dimitriadoy; D.L. Liu; H.S. Kantheti; S. Saghafinia; D. Chakravarty; F. Daian; Q. Gao; M.H. Bailey; W.W. Liang; S.M. Foltz; I. Shmulevich; L. Ding; Z. Heins; A. Ochoa; B. Gross; J. Gao; H. Zhang; R. Kundra; C. Kandoth; I. Bahceci; L. Dervishi; U. Dogrusoz; W. Zhou; H. Shen; P.W. Laird; G.P. Way; C.S. Greene; H. Liang; Y. Xiao; C. Wang; A. Iavarone; A.H. Berger; T.G. Bivona; A.J. Lazar; G.D. Hammer; T. Giordano; L.N. Kwong; G. McArthur; C. Huang; A.D. Tward; M.J. Frederick; F. McCormick; M. Meyerson; E.M. Van Allen; A.D. Cherniack; G. Ciriello; C. Sander; N. Schultz

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

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Date

5 avril 2018

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Anglais

Identifiants

doi: 10.1016/j.cell.2018.03.035
issn: 0092-8674

Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2018.03.035

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29625050

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1097-4172

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_03A6331C652C4

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Databases, Genetic; Genes, Neoplasm; Humans; Neoplasms/genetics; Neoplasms/pathology; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Signal Transduction/genetics; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Wnt Proteins/genetics; Wnt Proteins/metabolism; PanCanAtlas; TCGA; cancer genome atlas; cancer genomics; combination therapy; pan-cancer; precision oncology; signaling pathways; therapeutics; whole exome sequencing

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Carcinoma Cancers Malignancy (Cancer) Malignant tumors

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F. Sanchez-Vega et al., « Oncogenic Signaling Pathways in The Cancer Genome Atlas. », Serveur académique Lausannois, ID : 10.1016/j.cell.2018.03.035

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Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy.

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Oncogenic Signaling Pathways in The Cancer Genome Atlas.

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