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15 août 2017
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2017.07.065
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info:eu-repo/semantics/altIdentifier/pmid/28813682
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info:eu-repo/semantics/altIdentifier/eissn/2211-1247
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E24884033C826
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Mouse House mice Mus musculus House mouseCiter ce document
D. Mauvoisin et al., « Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. », Serveur académique Lausannois, ID : 10.1016/j.celrep.2017.07.065
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Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dependence are still poorly described. Here, we provide a comprehensive and rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases that correlated with the related metabolites in the regulated pathways. Mitochondrial proteins were over-represented among the rhythmically acetylated proteins and were highly correlated with SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD) + level-dependent, we show that NAD + is orchestrated by both feeding rhythms and the circadian clock through the NAD + salvage pathway but also via the nicotinamide riboside pathway. Hence, the diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver.