Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells.
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24 avril 2018
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2018.03.102
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info:eu-repo/semantics/altIdentifier/pmid/29694901
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M. Golumbeanu et al., « Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells. », Serveur académique Lausannois, ID : 10.1016/j.celrep.2018.03.102
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Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells. Here, we used a primary model of HIV latency and single-cell RNA sequencing to characterize transcriptional heterogeneity during HIV latency and reactivation. Our analysis identified transcriptional programs leading to successful reactivation of HIV expression.