Fiche du document
21 mai 2019
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.04.079
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31116987
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2211-1247
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CC1A2AB80EDD0
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
Fibrocytes DesmocytesCiter ce document
L.K. Dubey et al., « IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells. », Serveur académique Lausannois, ID : 10.1016/j.celrep.2019.04.079
Métriques
Partage / Export
Résumé
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5 + dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5 + dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13 + fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13 + fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4Rα-expressing B cells and CCL19 + fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13 + fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19 + fibroblasts in the development of CXCL13 + MRC-like cells and adaptive type 2 immunity in response to helminth infection.