Fiche du document
25 avril 2023
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2023.112378
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/37060566
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2211-1247
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_07D42F1D9F074
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
B lymphocytes Bursa equivalent cells Bone marrow derived cellsCiter ce document
E.M. Cox et al., « AKT activity orchestrates marginal zone B cell development in mice and humans. », Serveur académique Lausannois, ID : 10.1016/j.celrep.2023.112378
Métriques
Partage / Export
Résumé
The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) D + CD27 + B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgD + CD27 - and memory IgD - CD27 + B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans.