Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein.
Fiche du document
2012
- doi: 10.1016/j.chom.2012.01.007
- issn: 1931-3128
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chom.2012.01.007
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22305291
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1934-6069
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_51F286F85CB23
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Field guides Keys (Identification guides) Identification guides Hominians Homonids Great apes Hominidae Pongidae Man-like primates Forensic identification Lesser apes Small apes Hylobatids Hylobatidae Old World monkeysCiter ce document
N. Laguette et al., « Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein. », Serveur académique Lausannois, ID : 10.1016/j.chom.2012.01.007
Métriques
Partage / Export
Résumé
SAMHD1 has recently been identified as an HIV-1 restriction factor operating in myeloid cells. As a countermeasure, the Vpx accessory protein from HIV-2 and certain lineages of SIV have evolved to antagonize SAMHD1 by inducing its ubiquitin-proteasome-dependent degradation. Here, we show that SAMHD1 experienced strong positive selection episodes during primate evolution that occurred in the Catarrhini ancestral branch prior to the separation between hominoids (gibbons and great apes) and Old World monkeys. The identification of SAMHD1 residues under positive selection led to mapping the Vpx-interaction domain of SAMHD1 to its C-terminal region. Importantly, we found that while SAMHD1 restriction activity toward HIV-1 is evolutionarily maintained, antagonism of SAMHD1 by Vpx is species-specific. The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity.