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- doi: 10.1016/j.cmi.2016.02.013
- issn: 1198-743X
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Immunologic deficiency Immune deficiency Immunological deficiency Viral replication Replication of viruses Speech--Transcription Language and languages--Transcription Transcribing Steps Stairsteps Group dynamics Association Groups, Social C-type RNA viruses Leukoviruses Retroviridae RNA tumor viruses Oncornaviruses Leukemogenic viruses Oncoviruses Property--Law and legislation People Man Humanity (Human beings) Human race Mankind Homo sapiens Humankind Humans Pattern Model Virus genomes Viral genome TranscribingCiter ce document
A. Ciuffi, « The benefits of integration. », Serveur académique Lausannois, ID : 10.1016/j.cmi.2016.02.013
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Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host.