Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation.

F. López-Medrano; M. Fernández-Ruiz; J.T. Silva; P.L. Carver; C. van Delden; E. Merino; M.J. Pérez-Saez; M. Montero; J. Coussement; M. de Abreu Mazzolin; C. Cervera; L. Santos; N. Sabé; A. Scemla; E. Cordero; L. Cruzado-Vega; P.L. Martín-Moreno; Ó. Len; E. Rudas; A. Ponce de León; M. Arriola; R. Lauzurica; M.D. David; C. González-Rico; F. Henríquez-Palop; J. Fortún; M. Nucci; O. Manuel; J.R. Paño-Pardo; M. Montejo; A. Vena; B. Sánchez-Sobrino; A. Mazuecos; J. Pascual; J.P. Horcajada; T. Lecompte; A. Moreno; J. Carratalà; M. Blanes; D. Hernández; E.A. Hernández-Méndez; M.C. Fariñas; M. Perelló-Carrascosa; P. Muñoz; A. Andrés; J.M. Aguado

Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation.

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Anglais

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doi: 10.1016/j.cmi.2017.06.016
issn: 1198-743X

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cmi.2017.06.016

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info:eu-repo/semantics/altIdentifier/pmid/28652112

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info:eu-repo/semantics/altIdentifier/eissn/1469-0691

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3DD38C51841F5

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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case-control study; kidney transplantation; late invasive pulmonary aspergillosis; risk factors; Case-control study; Kidney transplantation; Late invasive pulmonary aspergillosis; Risk factors

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Aspergilloma

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F. López-Medrano et al., « Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation. », Serveur académique Lausannois, ID : 10.1016/j.cmi.2017.06.016

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To assess the risk factors for development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by centre and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease, and/or de novo malignancy. We identified 61 cases of late (>180 days after transplantation) IPA from 24 participating centres (accounting for 54.5% (61/112) of all cases included in the overall study). Most diagnoses (54.1% (33/61)) were established within the first 36 post-transplant months, although five cases occurred more than 10 years after transplantation. Overall mortality among cases was 47.5% (29/61). Compared with controls, cases were significantly older (p 0.010) and more likely to have pre-transplant chronic obstructive pulmonary disease (p 0.001) and a diagnosis of bloodstream infection (p 0.016) and IRE (p

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Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation.

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