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2013
- doi: 10.1016/j.coi.2013.02.008
- issn: 0952-7915
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Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cells Service of process Service of papers Abuse of process Process Retention (Psychology) Inflammatory mediators Mediators of inflammation Proof Understanding Linear complexes Cell degenerationCiter ce document
C. Dostert et al., « Innate and adaptive effects of inflammasomes on T cell responses. », Serveur académique Lausannois, ID : 10.1016/j.coi.2013.02.008
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Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8(+) T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies.