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- doi: 10.1016/j.coi.2021.06.009
- issn: 0952-7915
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coi.2021.06.009
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info:eu-repo/semantics/altIdentifier/pmid/34182216
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info:eu-repo/semantics/altIdentifier/eissn/1879-0372
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_537525B04EE57
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
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M. Eslami et al., « Function, occurrence and inhibition of different forms of BAFF. », Serveur académique Lausannois, ID : 10.1016/j.coi.2021.06.009
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B cell activating factor (BAFF or BLyS), an important cytokine for B cell survival and humoral immune responses, is targeted in the clinic for the treatment of systemic lupus erythematosus. This review focuses on the structure, function and inhibition profiles of membrane-bound BAFF, soluble BAFF 3-mer and soluble BAFF 60-mer, all of which have distinct properties. BAFF contains a loop region not required for receptor binding but essential for receptor activation via promotion of BAFF-to-BAFF contacts. This loop region additionally allows formation of BAFF 60-mer, in which epitopes of the BAFF inhibitor belimumab are inaccessible. If 60-mer forms in humans, it is predicted to be short-lived and to act locally because adult serum contains a BAFF 60-mer dissociating activity. Cord blood contains elevated levels of BAFF, part of which displays attributes of 60-mer, suggesting a role for this form of BAFF in the development of foetal or neonate B cells.