Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.

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Auteurs
Date

2009

Type de document
Périmètre
Langue
Identifiant
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.expneurol.2009.05.006

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/19445931

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/1090-2430[electronic]

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E921DA2008B64

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Activating Transcription Factor 3/metabolism; Analgesics, Opioid/pharmacology; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Hyperalgesia/drug therapy; Hyperalgesia/enzymology; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases/metabolism; Male; Melanoma/complications; Melanoma/drug therapy; Mice; Mice, Inbred C57BL; Morphine/pharmacology; Pain/drug therapy; Pain/enzymology; Pain Measurement; Peptides/pharmacology; Peptides/therapeutic use; Peripheral Nervous System Diseases/enzymology; Peripheral Nervous System Diseases/etiology; Sensory Receptor Cells/cytology; Sensory Receptor Cells/drug effects; Skin Neoplasms/complications; Skin Neoplasms/drug therapy

Sujets proches En

Cancer--Growth Neoplasm growth Tumor growth

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Y.J. Gao et al., « Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. », Serveur académique Lausannois, ID : 10.1016/j.expneurol.2009.05.006

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Cancer pain significantly affects the quality of cancer patients, and current treatments for this pain are limited. C-Jun N-terminal kinase (JNK) has been implicated in tumor growth and neuropathic pain sensitization. We investigated the role of JNK in cancer pain and tumor growth in a skin cancer pain model. Injection of luciferase-transfected B16-Fluc melanoma cells into a hindpaw of mouse induced robust tumor growth, as indicated by increase in paw volume and fluorescence intensity. Pain hypersensitivity in this model developed rapidly (

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