EPR spectroscopic evidence of iron-catalysed free radical formation in chronic mountain sickness: Dietary causes and vascular consequences.
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1 mai 2022
- doi: 10.1016/j.freeradbiomed.2022.03.028
- issn: 0891-5849
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.freeradbiomed.2022.03.028
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info:eu-repo/semantics/altIdentifier/pmid/35398201
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info:eu-repo/semantics/altIdentifier/eissn/1873-4596
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3874862149E45
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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Ideological extremists Political extremists EPR spectroscopy Electron spin resonance spectroscopy ESR spectroscopyCiter ce document
D.M. Bailey et al., « EPR spectroscopic evidence of iron-catalysed free radical formation in chronic mountain sickness: Dietary causes and vascular consequences. », Serveur académique Lausannois, ID : 10.1016/j.freeradbiomed.2022.03.028
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Chronic mountain sickness (CMS) is a high-altitude (HA) maladaptation syndrome characterised by elevated systemic oxidative-nitrosative stress (OXNOS) due to a free radical-mediated reduction in vascular nitric oxide (NO) bioavailability. To better define underlying mechanisms and vascular consequences, this study compared healthy male lowlanders (80 m, n = 10) against age/sex-matched highlanders born and bred in La Paz, Bolivia (3600 m) with (CMS+, n = 10) and without (CMS-, n = 10) CMS. Cephalic venous blood was assayed using electron paramagnetic resonance spectroscopy and reductive ozone-based chemiluminescence. Nutritional intake was assessed via dietary recall. Systemic vascular function and structure were assessed via flow-mediated dilatation, aortic pulse wave velocity and carotid intima-media thickness using duplex ultrasound and applanation tonometry. Basal systemic OXNOS was permanently elevated in highlanders (P =