Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijcha.2020.100496

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/32181323

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info:eu-repo/semantics/altIdentifier/pissn/2352-9067

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_5AF61B593B483

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

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ACS, Acute coronary syndrome; AE, Adverse Event; Acute coronary syndrome; CMRI, Cardiac Magnetic resonance imaging; CT, Computed tomography; Coronary computed tomography; ECG, Electrocardiogram; ED, Emergency department; FFR, Fractional Flow Reserve; FFR-CT; FFR-CT, FFR derived from coronary CT; Fractional Flow Reserve; Hs-Tn, High-sensitive troponins; MACE, Major adverse cardiac events; MI, Myocardial infraction; NSTE-ACS, Acute coronary syndromes without ST-segment elevation; NSTEMI, Non-ST-elevation myocardial infarction; PCI, Percutaneous Coronary Intervention; STEMI, ST-elevation myocardial infarction; URL, Upper Range Limit

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Blood-vessels--Radiography

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D. Meier et al., « Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale. », Serveur académique Lausannois, ID : 10.1016/j.ijcha.2020.100496

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In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS). The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS. We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared. In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.

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