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- doi: 10.1016/j.ijid.2023.01.043
- issn: 1201-9712
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2023.01.043
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info:eu-repo/semantics/altIdentifier/pmid/36775187
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info:eu-repo/semantics/altIdentifier/eissn/1878-3511
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4AD61D0F5DB76
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G.R. Joliat et al., « Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis. », Serveur académique Lausannois, ID : 10.1016/j.ijid.2023.01.043
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Résumé
Alveolar echinococcosis (AE) recurrence is one of the major stakes in patients undergoing surgery, the main curative treatment. Preliminary data demonstrated an effect of programmed death-ligand1 (PD-L1) inhibitors on AE proliferation in animals. The current study aimed to analyze the prognostic value of PD-L1 expression in tissue samples of patients with AE undergoing surgery. A cross-sectional study of patients operated for AE between 2002 and 2017 was performed. Patients with recurrence were matched 1: 2 with patients without recurrence. The matching criteria were PNM staging (P = hepatic localization of the parasite, N = extra-hepatic involvement of neighboring organs, and M = absence or presence of metastasis), resection status, preoperative albendazole treatment, and lesion size. PD-L1 immunohistochemistry staining was performed in surgical liver specimens. The expression of PD-L1 was assessed in immune cells. Disease-free survival was calculated using the Kaplan-Meier method. Among 68 consecutive patients, eight patients with recurrence were matched to 16 patients without recurrence. PD-L1 was overexpressed in patients with recurrence (recurrence: PD-L1