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19 décembre 2017
- doi: 10.1016/j.immuni.2017.11.028
- issn: 1074-7613
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Mots-clés
CD8-Positive T-Lymphocytes; Gene Expression Regulation; Humans; Male; Receptors, Antigen, T-CellSujets proches
Exhaustion Tiredness Lassitude WearinessCiter ce document
V. Chennupati et al., « Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells. », Serveur académique Lausannois, ID : 10.1016/j.immuni.2017.11.028
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Résumé
The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.