Inflammatory biomarkers in Alzheimer's disease plasma.

A.R. Morgan; S. Touchard; C. Leckey; O'Hagan C.; A.J. Nevado-Holgado; F. Barkhof; L. Bertram; O. Blin; I. Bos; V. Dobricic; S. Engelborghs; G. Frisoni; L. Frölich; S. Gabel; P. Johannsen; P. Kettunen; I. Kłoszewska; C. Legido-Quigley; A. Lleó; P. Martinez-Lage; P. Mecocci; K. Meersmans; J.L. Molinuevo; G. Peyratout; J. Popp; J. Richardson; I. Sala; P. Scheltens; J. Streffer; H. Soininen; M. Tainta-Cuezva; C. Teunissen; M. Tsolaki; R. Vandenberghe; P.J. Visser; S. Vos; L.O. Wahlund; A. Wallin; S. Westwood; H. Zetterberg; S. Lovestone; B.P. Morgan

Inflammatory biomarkers in Alzheimer's disease plasma.

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Auteurs

Discipline

Psychologie

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1016/j.jalz.2019.03.007
issn: 1552-5260

Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jalz.2019.03.007

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31047856

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1552-5279

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E5F2C092E3542

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

Mots-clés 0

Aged; Alzheimer Disease/blood; Alzheimer Disease/diagnosis; Amyloid beta-Peptides/blood; Biomarkers/blood; Cognitive Dysfunction/blood; Cognitive Dysfunction/diagnosis; Cohort Studies; Complement Factor B; Complement Factor H; Humans; Inflammation; Internationality; Prognosis; Alzheimer's disease; Biomarker; Complement; Plasma

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Alzheimer's dementia Alzheimer disease

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A.R. Morgan et al., « Inflammatory biomarkers in Alzheimer's disease plasma. », Serveur académique Lausannois, ID : 10.1016/j.jalz.2019.03.007

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Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation.

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Inflammatory biomarkers in Alzheimer's disease plasma.

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