Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.

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2008

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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neurobiolaging.2008.08.019

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info:eu-repo/semantics/altIdentifier/pmid/18950899

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info:eu-repo/semantics/altIdentifier/eissn/1558-1497

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C578C03066C24

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J. Miklossy et al., « Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. », Serveur académique Lausannois, ID : 10.1016/j.neurobiolaging.2008.08.019


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Abstract 0

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Abeta) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Abeta, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Abeta was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Abeta deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Abeta deposits and hyperphosphorylated tau may also occur in other organs than the brain.

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