Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.

Fiche du document

Date

2008

Discipline
Type de document
Périmètre
Langue
Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neurobiolaging.2008.08.019

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/18950899

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1558-1497

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C578C03066C24

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer



Citer ce document

J. Miklossy et al., « Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. », Serveur académique Lausannois, ID : 10.1016/j.neurobiolaging.2008.08.019


Métriques


Partage / Export

Résumé 0

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Abeta) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Abeta, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Abeta was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Abeta deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Abeta deposits and hyperphosphorylated tau may also occur in other organs than the brain.

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets

Sur les mêmes disciplines

Exporter en