Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.

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Date

2015

Type de document
Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2015.10.037

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/26606999

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1097-4199

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_712862D707D95

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Astrocytes/physiology; Astrocytes/ultrastructure; Clostridium botulinum type B/genetics; Clostridium botulinum type B/metabolism; Dendritic Spines/physiology; Dendritic Spines/ultrastructure; Excitatory Amino Acid Transporter 1/metabolism; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/genetics; Glial Fibrillary Acidic Protein/genetics; Glial Fibrillary Acidic Protein/metabolism; Hippocampus/cytology; Membrane Potentials/drug effects; Membrane Potentials/physiology; Mice; Mice, Transgenic; Neurogenesis/genetics; Neurogenesis/physiology; Neurons/physiology; Neurons/ultrastructure; Phosphopyruvate Hydratase/metabolism; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/metabolism; SNARE Proteins/genetics; SNARE Proteins/metabolism; Serine/pharmacology; Sodium Chloride/pharmacology; Synapses/genetics; Synapses/physiology; Synaptic Transmission/drug effects; Synaptic Transmission/genetics; Tamoxifen/pharmacology

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Glia (Neurology)

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S. Sultan et al., « Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes. », Serveur académique Lausannois, ID : 10.1016/j.neuron.2015.10.037

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Adult neurogenesis is regulated by the neurogenic niche, through mechanisms that remain poorly defined. Here, we investigated whether niche-constituting astrocytes influence the maturation of adult-born hippocampal neurons using two independent transgenic approaches to block vesicular release from astrocytes. In these models, adult-born neurons but not mature neurons showed reduced glutamatergic synaptic input and dendritic spine density that was accompanied with lower functional integration and cell survival. By taking advantage of the mosaic expression of transgenes in astrocytes, we found that spine density was reduced exclusively in segments intersecting blocked astrocytes, revealing an extrinsic, local control of spine formation. Defects in NMDA receptor (NMDAR)-mediated synaptic transmission and dendrite maturation were partially restored by exogenous D-serine, whose extracellular level was decreased in transgenic models. Together, these results reveal a critical role for adult astrocytes in local dendritic spine maturation, which is necessary for the NMDAR-dependent functional integration of newborn neurons.

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