A multi-contrast MRI study of microstructural brain damage in patients with mild cognitive impairment.
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2015
- doi: 10.1016/j.nicl.2015.06.003
- issn: 2213-1582
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Meter Prosody Metrics Knowledge, Classification of Cerebrum Mind Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people AgedCiter ce document
C. Granziera et al., « A multi-contrast MRI study of microstructural brain damage in patients with mild cognitive impairment. », Serveur académique Lausannois, ID : 10.1016/j.nicl.2015.06.003
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OBJECTIVES: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). METHODS: Forty-two MCI patients and 77 healthy controls (HC) underwent T1/T2* relaxometry as well as Magnetization Transfer (MT) MRI. Between-groups comparisons in MRI metrics were performed using permutation-based tests. Using MRI data, a generalized linear model (GLM) was computed to predict clinical performance and a support-vector machine (SVM) classification was used to classify MCI and HC subjects. RESULTS: Multi-parametric MRI data showed microstructural brain alterations in MCI patients vs HC that might be interpreted as: (i) a broad loss of myelin/cellular proteins and tissue microstructure in the hippocampus (p ≤ 0.01) and global white matter (p