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2018
- doi: 10.1016/j.nicl.2017.11.005
- issn: 2213-1582
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nicl.2017.11.005
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info:eu-repo/semantics/altIdentifier/pmid/29159062
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info:eu-repo/semantics/altIdentifier/eissn/2213-1582
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_72246D66FD0C2
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
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A. Verger et al., « Evaluation of factors influencing 18F-FET uptake in the brain. », Serveur académique Lausannois, ID : 10.1016/j.nicl.2017.11.005
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PET using the amino-acid O-(2- 18 F-fluoroethyl)-l-tyrosine ( 18 F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18 F-FET uptake in various brain areas, and thus affect quantification of 18 F-FET uptake in brain tumours. Negative 18 F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18 F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of 18 F-FET uptake in the brain. In women, SUV mean of 18 F-FET uptake in the brain was 23% higher than in men (p