Fiche du document
- doi: 10.1016/j.schres.2017.02.002
- issn: 0920-9964
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2017.02.002
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28189532
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1573-2509
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_22245425C64D2
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Psychotic disorders PsychosisCiter ce document
E. Geiser et al., « The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients. », Serveur académique Lausannois, ID : 10.1016/j.schres.2017.02.002
Métriques
Partage / Export
Résumé
Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data. Patients displayed significantly decreased AEPs over the time window of the P50/N100 complex resulting from significantly weaker responses in the left temporo-parietal lobe. The GPx/GR ratio significantly correlated with patients' brain activity during the time window of the P50/N100 in the medial frontal lobe. We show for the first time a direct coupling between electrophysiological indices of AEPs and peripheral redox dysregulation in psychosis patients. This coupling is limited to stages of auditory processing that are impaired relative to healthy controls and suggests a link between biochemical and sensory dysfunction. The data highlight the potential of low-level sensory processing as a trait-marker of psychosis.