Soy supplementation: Impact on gene expression in different tissues of ovariectomized rats and evaluation of the rat model to predict (post)menopausal health effect.
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2018
- doi: 10.1016/j.toxrep.2018.10.012
- issn: 2214-7500
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.toxrep.2018.10.012
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30425930
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2214-7500
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CB40B5F863812
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
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M.A. Islam et al., « Soy supplementation: Impact on gene expression in different tissues of ovariectomized rats and evaluation of the rat model to predict (post)menopausal health effect. », Serveur académique Lausannois, ID : 10.1016/j.toxrep.2018.10.012
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Résumé
This toxicogenomic study was conducted to predict (post)menopausal human health effects of commercial soy supplementation using ovariectomized rats as a model. Different target tissues (i.e. breast, uterus and sternum) and non-target tissues (i.e. peripheral blood mononuclear cells (PBMC), adipose and liver) of ovariectomized F344 rats exposed to a commercially available soy supplement for eight weeks, were investigated. Changes in gene expression in these tissues were analysed using whole-genome microarray analysis. No correlation in changes in gene expression were observed among different tissues, indicating tissue specific effects of soy isoflavone supplementation. Out of 87 well-established estrogen responsive genes (ERGs), only 19 were found to be significantly regulated (p