Fiche du document
24 mai 2021
- doi: 10.1021/jacsau.0c00074
- issn: 2691-3704
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1021/jacsau.0c00074
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/34056635
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2691-3704
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_2FC489BC07117
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
Integument (Skin) CutisCiter ce document
Y. Zhu et al., « Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning. », Serveur académique Lausannois, ID : 10.1021/jacsau.0c00074
Métriques
Partage / Export
Résumé
Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detection of skin disorders. Within this methodology, adhesive sampling and laser desorption ionization mass spectrometry are coordinated to record skin surface molecular mass in minutes. Automated result interpretation is achieved by data learning, using similarity scoring and machine learning algorithms. Feasibility of the methodology has been demonstrated after testing a total of 117 healthy, benign-disordered, or malignant-disordered skins. Remarkably, skin malignancy, using melanoma as a proof of concept, was detected with 100% accuracy already at early stages when the lesions were submillimeter-sized, far beyond the detection limit of most existing noninvasive diagnosis tools. Moreover, the malignancy development over time has also been monitored successfully, showing the potential to predict skin disorder progression. Capable of detecting skin alterations at the molecular level in a nonsurgical and time-saving manner, this analytical chemistry platform is promising to build personalized skin care.