Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

J.R. Perry; F. Day; C.E. Elks; P. Sulem; D.J. Thompson; T. Ferreira; C. He; D.I. Chasman; T. Esko; G. Thorleifsson; E. Albrecht; W.Q. Ang; T. Corre; D.L. Cousminer; B. Feenstra; N. Franceschini; A. Ganna; A.D. Johnson; S. Kjellqvist; K.L. Lunetta; G. McMahon; I.M. Nolte; L. Paternoster; E. Porcu; A.V. Smith; L. Stolk; A. Teumer; N. Tšernikova; E. Tikkanen; S. Ulivi; E.K. Wagner; N. Amin; L.J. Bierut; E.M. Byrne; J.J. Hottenga; D.L. Koller; M. Mangino; T.H. Pers; L.M. Yerges-Armstrong; J. Hua Zhao; I.L. Andrulis; H. Anton-Culver; F. Atsma; S. Bandinelli; M.W. Beckmann; J. Benitez; C. Blomqvist; S.E. Bojesen; M.K. Bolla; B. Bonanni; H. Brauch; H. Brenner; J.E. Buring; J. Chang-Claude; S. Chanock; J. Chen; G. Chenevix-Trench; J.M. Collée; F.J. Couch; D. Couper; A.D. Coviello; A. Cox; K. Czene; D'adamo A.P.; G. Davey Smith; I. De Vivo; E.W. Demerath; J. Dennis; P. Devilee; A.K. Dieffenbach; A.M. Dunning; G. Eiriksdottir; J.G. Eriksson; P.A. Fasching; L. Ferrucci; D. Flesch-Janys; H. Flyger; T. Foroud; L. Franke; M.E. Garcia; M. García-Closas; F. Geller; E.E. de Geus; G.G. Giles; D.F. Gudbjartsson; V. Gudnason; P. Guénel; S. Guo; P. Hall; U. Hamann; R. Haring; C.A. Hartman; A.C. Heath; A. Hofman; M.J. Hooning; J.L. Hopper; F.B. Hu; D.J. Hunter; D. Karasik; D.P. Kiel; J.A. Knight; V.M. Kosma; Z. Kutalik; S. Lai; D. Lambrechts; A. Lindblom; R. Mägi; P.K. Magnusson; A. Mannermaa; N.G. Martin; G. Masson; P.F. McArdle; W.L. McArdle; M. Melbye; K. Michailidou; E. Mihailov; L. Milani; R.L. Milne; H. Nevanlinna; P. Neven; E.A. Nohr; A.J. Oldehinkel; B.A. Oostra; A. Palotie; M. Peacock; N.L. Pedersen; P. Peterlongo; J. Peto; P.D. Pharoah; D.S. Postma; A. Pouta; K. Pylkäs; P. Radice; S. Ring; F. Rivadeneira; A. Robino; L.M. Rose; A. Rudolph; V. Salomaa; S. Sanna; D. Schlessinger; M.K. Schmidt; M.C. Southey; U. Sovio; M.J. Stampfer; D. Stöckl; A.M. Storniolo; N.J. Timpson; J. Tyrer; J.A. Visser; P. Vollenweider; H. Völzke; G. Waeber; M. Waldenberger; H. Wallaschofski; Q. Wang; G. Willemsen; R. Winqvist; B.H. Wolffenbuttel; M.J. Wright; D.I. Boomsma; M.J. Econs; K.T. Khaw; R.J. Loos; M.I. McCarthy; G.W. Montgomery; J.P. Rice; E.A. Streeten; U. Thorsteinsdottir; C.M. van Duijn; B.Z. Alizadeh; S. Bergmann; E. Boerwinkle; H.A. Boyd; L. Crisponi; P. Gasparini; C. Gieger; T.B. Harris; E. Ingelsson; M.R. Järvelin; P. Kraft; D. Lawlor; A. Metspalu; C.E. Pennell; P.M. Ridker; H. Snieder; T.I. Sørensen; T.D. Spector; D.P. Strachan; A.G. Uitterlinden; N.J. Wareham; E. Widen; M. Zygmunt; A. Murray; D.F. Easton; K. Stefansson; J.M. Murabito; K.K. Ong

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

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Date

2 octobre 2014

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Articles

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Publications

Langue

Anglais

Identifiants

doi: 10.1038/nature13545
issn: 0028-0836

Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/nature13545

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25231870

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1476-4687

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7816C9E4E3E58

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adolescent; Age Factors; Alleles; Body Mass Index; Breast Neoplasms/genetics; Cardiovascular Diseases/genetics; Child; Diabetes Mellitus, Type 2/genetics; Europe/ethnology; Female; Genetic Loci/genetics; Genome-Wide Association Study; Genomic Imprinting/genetics; Humans; Hypothalamo-Hypophyseal System/physiology; Intercellular Signaling Peptides and Proteins/genetics; Male; Membrane Proteins/genetics; Menarche/genetics; Obesity/genetics; Ovary/physiology; Parents; Polymorphism, Single Nucleotide/genetics; Potassium Channels, Tandem Pore Domain/genetics; Proteins/genetics; Quantitative Trait Loci/genetics; Receptors, GABA-B/metabolism; Receptors, Retinoic Acid/metabolism; Ribonucleoproteins/genetics

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People Man Humanity (Human beings) Human race Mankind Homo sapiens Humankind Humans Breasts BMI (Body mass index)

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J.R. Perry et al., « Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. », Serveur académique Lausannois, ID : 10.1038/nature13545

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Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

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