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2014
- doi: 10.1038/ncomms4578
- issn: 2041-1723
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info:eu-repo/semantics/altIdentifier/pmid/24709914
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Microtubule proteins Tubulin Psittacosis-lymphogranuloma-trachoma organisms PLT agents Spontaneous abortion Abortion, Spontaneous Micro-organisms, Pathogenic Disease-causing microorganisms Pathogens Understanding Synthesis, Biological Biological synthesisCiter ce document
N. Jacquier et al., « Cell wall precursors are required to organize the chlamydial division septum. », Serveur académique Lausannois, ID : 10.1038/ncomms4578
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Members of the Chlamydiales order are major bacterial pathogens that divide at mid-cell, without a sequence homologue of the FtsZ cytokinetic tubulin and without a classical peptidoglycan cell wall. Moreover, the spatiotemporal mechanisms directing constriction in Chlamydia are not known. Here we show that the MreB actin homologue and its conserved regulator RodZ localize to the division furrow in Waddlia chondrophila, a member of the Chlamydiales order implicated in human miscarriage. RodZ is recruited to the septal site earlier than MreB and in a manner that depends on biosynthesis of the peptidoglycan precursor lipid II by the MurA enzyme. By contrast, crosslinking of lipid II peptides by the Pbp3 transpeptidase disperses RodZ from the septum. Altogether, these findings provide a cytological framework for understanding chlamydial cytokinesis driven by septal cell wall synthesis.