Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

H.R. Warren; E. Evangelou; C.P. Cabrera; H. Gao; M. Ren; B. Mifsud; I. Ntalla; P. Surendran; C. Liu; J.P. Cook; A.T. Kraja; F. Drenos; M. Loh; N. Verweij; J. Marten; I. Karaman; M.P. Lepe; O'Reilly P.F.; J. Knight; H. Snieder; N. Kato; J. He; E.S. Tai; M.A. Said; D. Porteous; M. Alver; N. Poulter; M. Farrall; R.T. Gansevoort; S. Padmanabhan; R. Mägi; A. Stanton; J. Connell; S.J. Bakker; A. Metspalu; D.C. Shields; S. Thom; M. Brown; P. Sever; T. Esko; C. Hayward; P. van der Harst; D. Saleheen; R. Chowdhury; J.C. Chambers; D.I. Chasman; A. Chakravarti; C. Newton-Cheh; C.M. Lindgren; D. Levy; J.S. Kooner; B. Keavney; M. Tomaszewski; N.J. Samani; J.M. Howson; M.D. Tobin; P.B. Munroe; G.B. Ehret; L.V. Wain

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Fiche du document

Auteurs

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1038/ng.3768
issn: 1061-4036

Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/ng.3768

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28135244

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1546-1718

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3DE32D5D8A366

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Sujets proches En

Blood--Pressure

Citer ce document

H.R. Warren et al., « Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. », Serveur académique Lausannois, ID : 10.1038/ng.3768

Partage / Export

Résumé 0

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

{"uri":"10.1038\/ng.3768","creators":[{"id":"warren_h_r","lastname":"Warren"},{"id":"evangelou_e","lastname":"Evangelou"},{"id":"cabrera_c_p","lastname":"Cabrera"},{"id":"gao_h","lastname":"Gao"},{"id":"ren_m","lastname":"Ren"},{"id":"mifsud_b","lastname":"Mifsud"},{"id":"ntalla_i","lastname":"Ntalla"},{"id":"surendran_p","lastname":"Surendran"},{"id":"liu_c","lastname":"Liu"},{"id":"cook_j_p","lastname":"Cook"},{"id":"kraja_a_t","lastname":"Kraja"},{"id":"drenos_f","lastname":"Drenos"},{"id":"loh_m","lastname":"Loh"},{"id":"verweij_n","lastname":"Verweij"},{"id":"marten_j","lastname":"Marten"},{"id":"karaman_i","lastname":"Karaman"},{"id":"lepe_m_p","lastname":"Lepe"},{"id":"o_reilly_p_f","lastname":"O'Reilly, P.F."},{"id":"knight_j","lastname":"Knight"},{"id":"snieder_h","lastname":"Snieder"},{"id":"kato_n","lastname":"Kato"},{"id":"he_j","lastname":"He"},{"id":"tai_e_s","lastname":"Tai"},{"id":"said_m_a","lastname":"Said"},{"id":"porteous_d","lastname":"Porteous"},{"id":"alver_m","lastname":"Alver"},{"id":"poulter_n","lastname":"Poulter"},{"id":"farrall_m","lastname":"Farrall"},{"id":"gansevoort_r_t","lastname":"Gansevoort"},{"id":"padmanabhan_s","lastname":"Padmanabhan"},{"id":"magi_r","lastname":"M\u00e4gi"},{"id":"stanton_a","lastname":"Stanton"},{"id":"connell_j","lastname":"Connell"},{"id":"bakker_s_j","lastname":"Bakker"},{"id":"metspalu_a","lastname":"Metspalu"},{"id":"shields_d_c","lastname":"Shields"},{"id":"thom_s","lastname":"Thom"},{"id":"brown_m","lastname":"Brown"},{"id":"sever_p","lastname":"Sever"},{"id":"esko_t","lastname":"Esko"},{"id":"hayward_c","lastname":"Hayward"},{"id":"van_der_harst_p","lastname":"van der Harst"},{"id":"saleheen_d","lastname":"Saleheen"},{"id":"chowdhury_r","lastname":"Chowdhury"},{"id":"chambers_j_c","lastname":"Chambers"},{"id":"chasman_d_i","lastname":"Chasman"},{"id":"chakravarti_a","lastname":"Chakravarti"},{"id":"newton_cheh_c","lastname":"Newton-Cheh"},{"id":"lindgren_c_m","lastname":"Lindgren"},{"id":"levy_d","lastname":"Levy"},{"id":"kooner_j_s","lastname":"Kooner"},{"id":"keavney_b","lastname":"Keavney"},{"id":"tomaszewski_m","lastname":"Tomaszewski"},{"id":"samani_n_j","lastname":"Samani"},{"id":"howson_j_m","lastname":"Howson"},{"id":"tobin_m_d","lastname":"Tobin"},{"id":"munroe_p_b","lastname":"Munroe"},{"id":"ehret_g_b","lastname":"Ehret"},{"id":"wain_l_v","lastname":"Wain"}]}

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Fiche du document

Sujets proches En

Citer ce document

Métriques

Partage / Export

Résumé 0

Par les mêmes auteurs

Sur les mêmes sujets

Exporter en