Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.
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- doi: 10.1038/ng.3835
- issn: 1061-4036
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HCV (Hepatitis C virus) Units of inheritance Units of heredity Immunological system Parenterally-transmitted non-A, non-B hepatitis Non-A, non-B hepatitis, Parenterally-transmitted Hepatitis, Non-A, non-B Methods of analysis Analysis and chemistry Analytical methods Chemical analysis Analysis methods Analysis and examinationCiter ce document
M.A. Ansari et al., « Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus. », Serveur académique Lausannois, ID : 10.1038/ng.3835
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Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles of genes encoding human leukocyte antigen molecules and genes encoding components of the interferon lambda innate immune system drive viral polymorphism. Additionally, we show that IFNL4 genotypes determine HCV viral load through a mechanism dependent on a specific amino acid residue in the HCV NS5A protein. These findings highlight the interplay between the innate immune system and the viral genome in HCV control.