Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Fiche du document
2010
- doi: 10.1038/ng.521
- issn: 1061-4036
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/ng.521
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/20081857
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1546-1718
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E30C7201086A6
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Bigotry Tolerance Intolerance Group dynamics Association Groups, Social Ribose nucleic acid Ribonucleic acid Type II diabetes Ketosis resistant diabetes Adult onset diabetes Noninsulin-dependent diabetes NIDDM (Diabetes) Stable diabetes Maturity onset diabetes Type 2 diabetesCiter ce document
R. Saxena et al., « Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. », Serveur académique Lausannois, ID : 10.1038/ng.521
Métriques
Partage / Export
Résumé
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).