Cracking the BAFF code.

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Date

2009

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Périmètre
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Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/nri2572

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/19521398

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/1474-1741[electronic]

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_0347D39CE7CD7

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Autoimmunity/immunology; B-Cell Activating Factor/immunology; B-Cell Activating Factor/metabolism; B-Cell Maturation Antigen/immunology; B-Cell Maturation Antigen/metabolism; B-Lymphocyte Subsets/immunology; B-Lymphocyte Subsets/metabolism; Humans; Immune Tolerance/immunology; Ligands; Lymphocyte Activation/immunology; Signal Transduction/immunology; Toll-Like Receptors/immunology; Toll-Like Receptors/metabolism; Transmembrane Activator and CAML Interactor Protein/immunology; Transmembrane Activator and CAML Interactor Protein/metabolism; Tumor Necrosis Factor Ligand Superfamily Member 13/immunology; Tumor Necrosis Factor Ligand Superfamily Member 13/metabolism; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/immunology; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism

Sujets proches En

Lymphotoxin TNF (Immunology) Cachectin

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F. Mackay et al., « Cracking the BAFF code. », Serveur académique Lausannois, ID : 10.1038/nri2572

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The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess of BAFF leads to the development of autoimmune disorders in animal models, and high levels of BAFF have been detected in the serum of patients with various autoimmune conditions. In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance. We also outline the mechanisms of BAFF signalling, the impact of ligand oligomerization on receptor activation and the progress of BAFF-depleting agents in the clinical setting.

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