From concepts to treatment: a dialog between a preclinical researcher and a clinician in addiction medicine.
Fiche du document
21 septembre 2022
- doi: 10.1038/s41398-022-02177-5
- issn: 2158-3188
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41398-022-02177-5
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/36130939
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2158-3188
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_5430F538BEC46
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Mots-clés
Addiction Medicine; Animals; Behavior, Addictive; Ethanol; Substance-Related Disorders/therapySujets proches
Clinical sciences Medical professionCiter ce document
Y. Vandaele et al., « From concepts to treatment: a dialog between a preclinical researcher and a clinician in addiction medicine. », Serveur académique Lausannois, ID : 10.1038/s41398-022-02177-5
Métriques
Partage / Export
Résumé
The debate surrounding the brain disease model and the associated questioning of the relevance of animal models is polarizing the field of addiction, and tends to widen the gap between preclinical research and addiction medicine. Here, we aimed at bridging this gap by establishing a dialog between a preclinical researcher and a clinician in addiction medicine. Our objective was to evaluate animal models and the neuroscientific conceptualization of addiction in light of alcohol or drug dependence and treatment in patients struggling with an addiction. We sought to determine how preclinical research influenced addiction medicine over past decades, and reciprocally, what can preclinical researchers learn from addiction medicine that could lead to more effective approaches. In this dialog, we talk about the co-evolution of addiction concepts and treatments from neuroscientific and medical perspectives. This dialog illustrates the reciprocal influences and mutual enrichment between the two disciplines and reveals that, although preclinical research might not produce new pharmacotherapies, it does shape the theoretical conceptualization of addiction and could thereby contribute to the implementation of therapeutic approaches.
