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1 décembre 2017
- doi: 10.1038/s41467-017-01930-5
- issn: 2041-1723
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S.H. Klompmaker et al., « Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter. », Serveur académique Lausannois, ID : 10.1038/s41467-017-01930-5
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Cells acquire free metals through plasma membrane transporters. But, in natural settings, sequestering agents often render metals inaccessible to transporters, limiting metal bioavailability. Here we identify a pathway for metal acquisition, allowing cells to cope with this situation. Under limited bioavailability of Mg 2+ , yeast cells upregulate fluid-phase endocytosis and transfer solutes from the environment into their vacuole, an acidocalcisome-like compartment loaded with highly concentrated polyphosphate. We propose that this anionic inorganic polymer, which is an avid chelator of Mg 2+ , serves as an immobilized cation filter that accumulates Mg 2+ inside these organelles. It thus allows the vacuolar exporter Mnr2 to efficiently transfer Mg 2+ into the cytosol. Leishmania parasites also employ acidocalcisomal polyphosphate to multiply in their Mg 2+ -limited habitat, the phagolysosomes of inflammatory macrophages. This suggests that the pathway for metal uptake via endocytosis, acidocalcisomal polyphosphates and export into the cytosol, which we term EAPEC, is conserved.