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8 mars 2018
- doi: 10.1038/s41467-018-03386-7
- issn: 2041-1723
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-018-03386-7
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info:eu-repo/semantics/altIdentifier/pmid/29520006
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4EF44BEFF6891
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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L. Ferlauto et al., « Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. », Serveur académique Lausannois, ID : 10.1038/s41467-018-03386-7
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Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.