An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing.
Fiche du document
12 octobre 2018
- doi: 10.1038/s41467-018-06453-1
- issn: 2041-1723
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-018-06453-1
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30315166
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2041-1723
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A5215CD5F4B56
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Glutamate Expressive behavior Acids, FattyCiter ce document
J.A. Sánchez-Alcañiz et al., « An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. », Serveur académique Lausannois, ID : 10.1038/s41467-018-06453-1
Métriques
Partage / Export
Résumé
Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations in diverse gustatory organs in larvae and adults. We characterise IR56d, which defines two anatomically-distinct neuron classes in the proboscis: one responds to carbonated solutions and fatty acids while the other represents a subset of sugar- and fatty acid-sensing cells. Mutational analysis indicates that IR56d, together with the broadly-expressed co-receptors IR25a and IR76b, is essential for physiological responses to carbonation and fatty acids, but not sugars. We further demonstrate that carbonation and fatty acids both promote IR56d-dependent attraction of flies, but through different behavioural outputs. Our work provides a toolkit for investigating taste functions of IRs, defines a subset of these receptors required for carbonation sensing, and illustrates how the gustatory system uses combinatorial expression of sensory molecules in distinct neurons to coordinate behaviour. Erratum with Publisher Correction: An Expression Atlas of Variant Ionotropic Glutamate Receptors Identifies a Molecular Basis of Carbonation Sensing JA Sánchez-Alcañiz et al. Nat Commun 11 (1), 1131. 2020. PMID 32098953.