Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41587-021-01072-6

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/34782741

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info:eu-repo/semantics/altIdentifier/eissn/1546-1696

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_18BFBDDF727B5

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

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Animals; Antigens, Neoplasm/genetics; CD8-Positive T-Lymphocytes; Humans; Lymphocytes, Tumor-Infiltrating; Mice; Neoplasms/genetics; Neoplasms/therapy; Receptors, Antigen, T-Cell/genetics; T-Lymphocytes

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M. Arnaud et al., « Sensitive identification of neoantigens and cognate TCRs in human solid tumors. », Serveur académique Lausannois, ID : 10.1038/s41587-021-01072-6

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The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.

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