Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

J.J. Lee; R. Wedow; A. Okbay; E. Kong; O. Maghzian; M. Zacher; P. Bowers; J. Sidorenko; R. Karlsson Linnér; M.A. Fontana; T. Kundu; C. Lee; H. Li; R. Li; R. Royer; P.N. Timshel; R.K. Walters; E.A. Willoughby; L. Yengo; M. Alver; Y. Bao; D.W. Clark; F.R. Day; N.A. Furlotte; P.K. Joshi; K.E. Kemper; A. Kleinman; C. Langenberg; R. Mägi; J.W. Trampush; S.S. Verma; Y. Wu; M. Lam; J.H. Zhao; Z. Zheng; J.D. Boardman; H. Campbell; J. Freese; K.M. Harris; C. Hayward; P. Herd; M. Kumari; T. Lencz; J. Luan; A.K. Malhotra; A. Metspalu; L. Milani; K.K. Ong; JRB Perry; D.J. Porteous; M.D. Ritchie; M.C. Smart; B.H. Smith; J.Y. Tung; N.J. Wareham; J.F. Wilson; J.P. Beauchamp; D.C. Conley; T. Esko; S.F. Lehrer; PKE Magnusson; S. Oskarsson; T.H. Pers; M.R. Robinson; K. Thom; C. Watson; C.F. Chabris; M.N. Meyer; D.I. Laibson; J. Yang; M. Johannesson; P.D. Koellinger; P. Turley; P.M. Visscher; D.J. Benjamin; D. Cesarini

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

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Date

23 juillet 2018

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1038/s41588-018-0147-3
issn: 1061-4036

Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41588-018-0147-3

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30038396

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1546-1718

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C6C6C43DAEB11

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

Mots-clés 0

Adult; Aged; Aged, 80 and over; Cohort Studies; Educational Status; Female; Genome-Wide Association Study/methods; Humans; Male; Middle Aged; Multifactorial Inheritance; Phenotype; Polymorphism, Single Nucleotide

Sujets proches En

Level of education completed Attainment, Educational Education level completed School years completed Years of school completed

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J.J. Lee et al., « Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. », Serveur académique Lausannois, ID : 10.1038/s41588-018-0147-3

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Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

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