Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

A.E. Justice; T. Karaderi; H.M. Highland; K.L. Young; M. Graff; Y. Lu; V. Turcot; P.L. Auer; R.S. Fine; X. Guo; C. Schurmann; A. Lempradl; E. Marouli; A. Mahajan; T.W. Winkler; A.E. Locke; T. Esko; S. Vedantam; A. Giri; K.S. Lo; T. Alfred; P. Mudgal; MCY Ng; M.F. Feitosa; A.K. Manning; S.M. Willems; S. Sivapalaratnam; G. Abecasis; D.S. Alam; M. Allison; P. Amouyel; Z. Arzumanyan; B. Balkau; L. Bastarache; S. Bergmann; L.F. Bielak; M. Blüher; M. Boehnke; H. Boeing; E. Boerwinkle; C.A. Böger; E.P. Bottinger; D.W. Bowden; I. Brandslund; L. Broer; A.A. Burt; A.S. Butterworth; M.J. Caulfield; G. Cesana; J.C. Chambers; D.I. Chasman; Y.I. Chen; R. Chowdhury; C. Christensen; A.Y. Chu; F.S. Collins; J.P. Cook; A.J. Cox; D.S. Crosslin; J. Danesh; PIW de Bakker; S. Denus; R. Mutsert; G. Dedoussis; E.W. Demerath; J.G. Dennis; J.C. Denny; E.D. Angelantonio; M. Dörr; F. Drenos; M.P. Dubé; A.M. Dunning; D.F. Easton; P. Elliott; E. Evangelou; A.E. Farmaki; S. Feng; E. Ferrannini; J. Ferrieres; J.C. Florez; M. Fornage; C.S. Fox; P.W. Franks; N. Friedrich; W. Gan; I. Gandin; P. Gasparini; V. Giedraitis; G. Girotto; M. Gorski; H. Grallert; N. Grarup; M.L. Grove; S. Gustafsson; J. Haessler; T. Hansen; A.T. Hattersley; C. Hayward; I.M. Heid; O.L. Holmen; G.K. Hovingh; JMM Howson; Y. Hu; Y.J. Hung; K. Hveem; M.A. Ikram; E. Ingelsson; A.U. Jackson; G.P. Jarvik; Y. Jia; T. Jørgensen; P. Jousilahti; J.M. Justesen; B. Kahali; M. Karaleftheri; SLR Kardia; F. Karpe; F. Kee; H. Kitajima; P. Komulainen; J.S. Kooner; P. Kovacs; B.K. Krämer; K. Kuulasmaa; J. Kuusisto; M. Laakso; T.A. Lakka; D. Lamparter; L.A. Lange; C. Langenberg; E.B. Larson; N.R. Lee; W.J. Lee; T. Lehtimäki; C.E. Lewis; H. Li; J. Li; L.A. Lin; X. Lin; L. Lind; J. Lindström; A. Linneberg; C.T. Liu; D.J. Liu; J. Luan; L.P. Lyytikäinen; S. MacGregor; R. Mägi; S. Männistö; G. Marenne; J. Marten; NGD Masca; M.I. McCarthy; K. Meidtner; E. Mihailov; L. Moilanen; M. Moitry; A. Morgan; A.P. Morris; P.B. Munroe; N. Narisu; C.P. Nelson; M. Neville; I. Ntalla; J.R. O'Connell; K.R. Owen; O. Pedersen; G.M. Peloso; C.E. Pennell; M. Perola; J.A. Perry; JRB Perry; T.H. Pers; A. Ewing; O. Polasek; O.T. Raitakari; A. Rasheed; C.K. Raulerson; R. Rauramaa; D.F. Reilly; A.P. Reiner; P.M. Ridker; M.A. Rivas; N.R. Robertson; A. Robino; I. Rudan; K.S. Ruth; D. Saleheen; V. Salomaa; N.J. Samani; P.J. Schreiner; M.B. Schulze; R.A. Scott; X. Sim; A.J. Slater; K.S. Small; B.H. Smith; J.A. Smith; L. Southam; T.D. Spector; E.K. Speliotes; K. Stefansson; V. Steinthorsdottir; K.E. Stirrups; K. Strauch; H.M. Stringham; M. Stumvoll; L. Sun; P. Surendran; KMA Swart; J.C. Tardif; K.D. Taylor; A. Teumer; D.J. Thompson; G. Thorleifsson; U. Thorsteinsdottir; B.H. Thuesen; A. Tönjes; M. Torres; E. Tsafantakis; J. Tuomilehto; A.G. Uitterlinden; M. Uusitupa; C.M. van Duijn; M. Vanhala; R. Varma; S.H. Vermeulen; H. Vestergaard; V. Vitart; T.F. Vogt; D. Vuckovic; L.E. Wagenknecht; M. Walker; L. Wallentin; F. Wang; C.A. Wang; S. Wang; N.J. Wareham; H.R. Warren; D.M. Waterworth; J. Wessel; H.D. White; C.J. Willer; J.G. Wilson; A.R. Wood; Y. Wu; H. Yaghootkar; J. Yao; R. Young; E. Zeggini; X. Zhan; W. Zhang; J.H. Zhao; W. Zhao; H. Zheng; W. Zhou; M.C. Zillikens; F. Rivadeneira; I.B. Borecki; J.A. Pospisilik; P. Deloukas; T.M. Frayling; G. Lettre; K.L. Mohlke; J.I. Rotter; Z. Kutalik; J.N. Hirschhorn; L.A. Cupples; RJF Loos; K.E. North; C.M. Lindgren

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Fiche du document

Auteurs

Discipline

Anthropologie biologique

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1038/s41588-018-0334-2
issn: 1061-4036

Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41588-018-0334-2

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30778226

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1546-1718

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3FE73F14651D2

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Body Fat Distribution/methods; Body Mass Index; Case-Control Studies; Drosophila/genetics; Exome/genetics; Female; Gene Frequency/genetics; Genetic Predisposition to Disease/genetics; Genetic Variation/genetics; Genome-Wide Association Study/methods; Homeostasis/genetics; Humans; Lipids/genetics; Male; Proteins/genetics; Risk Factors; Waist-Hip Ratio/methods

Sujets proches En

Units of inheritance Units of heredity Fats

Citer ce document

A.E. Justice et al., « Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. », Serveur académique Lausannois, ID : 10.1038/s41588-018-0334-2

Partage / Export

Résumé 0

Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF

Par les mêmes auteurs

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Fiche du document

Mots-clés 0

Sujets proches En

Citer ce document

Métriques

Partage / Export

Résumé 0

Par les mêmes auteurs

Sur les mêmes sujets

Sur les mêmes disciplines