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31 octobre 2019
- doi: 10.1038/s41597-019-0171-x
- issn: 2052-4463
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CE11322FA2839
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Sleeping Slumber Scientific research Science research Science--Research Mouse House mice Mus musculus House mouseCiter ce document
M. Jan et al., « A multi-omics digital research object for the genetics of sleep regulation. », Serveur académique Lausannois, ID : 10.1038/s41597-019-0171-x
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Résumé
With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wake phenome. To facilitate a meaningful and efficient re-use of this public resource by others we designed, describe in detail, and made available a Digital Research Object (DRO), embedding data, documentation, and analytics. We present and discuss both the advantages and limitations of our multi-modal resource and analytic pipeline. The reproducibility of the results was tested by a bioinformatician not implicated in the original project and the robustness of results was assessed by re-annotating genetic and transcriptome data from the mm9 to the mm10 mouse genome assembly.