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2018
- doi: 10.1038/s41598-018-24339-6
- issn: 2045-2322
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S. Saberi-Moghadam et al., « In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation. », Serveur académique Lausannois, ID : 10.1038/s41598-018-24339-6
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Prolonged wakefulness leads to a homeostatic response manifested in increased amplitude and number of electroencephalogram (EEG) slow waves during recovery sleep. Cortical networks show a slow oscillation when the excitatory inputs are reduced (during slow wave sleep, anesthesia), or absent (in vitro preparations). It was recently shown that a homeostatic response to electrical stimulation can be induced in cortical cultures. Here we used cortical cultures grown on microelectrode arrays and stimulated them with a cocktail of waking neuromodulators. We found that recovery from stimulation resulted in a dose-dependent homeostatic response. Specifically, the inter-burst intervals decreased, the burst duration increased, the network showed higher cross-correlation and strong phasic synchronized burst activity. Spectral power below