Fiche du document
14 mars 2019
- doi: 10.1038/s41598-019-40933-8
- issn: 2045-2322
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-40933-8
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30872676
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2045-2322
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_07410EEFFC5B3
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Sujets proches
K cells Natural killer cells NK cellsCiter ce document
K. de Jonge et al., « Circulating CD56bright NK cells inversely correlate with survival of melanoma patients. », Serveur académique Lausannois, ID : 10.1038/s41598-019-40933-8
Métriques
Partage / Export
Résumé
The roles of NK cells in human melanoma remain only partially understood. We characterized NK cells from peripheral blood ex vivo by flow cytometry obtained from late stage (III/IV) melanoma patients. Interestingly, we found that the abundance of CD56 bright NK cells negatively correlate with overall patient survival, together with distant metastases, in a multivariate cox regression analysis. The patients' CD56 bright NK cells showed upregulation of CD11a, CD38 and CD95 as compared to healthy controls, pointing to an activated phenotype as well as a possible immune regulatory role in melanoma patients. After stimulation in vitro, CD56 bright NK cells produced less TNFα and GMCSF in patients than controls. Furthermore, IFNγ production by the CD56 bright NK cells correlated inversely with overall survival. Our results highlight that abundance and function of CD56 bright NK cells are associated with melanoma patient survival, emphasizing the potential of NK cell subsets for biomarker discovery and future therapeutic targeting.