Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes.
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28 juin 2019
- doi: 10.1038/s41598-019-45260-6
- issn: 2045-2322
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-45260-6
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31253838
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info:eu-repo/semantics/altIdentifier/eissn/2045-2322
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9509A2FF11D85
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cellsCiter ce document
M. Alibashe-Ahmed et al., « Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes. », Serveur académique Lausannois, ID : 10.1038/s41598-019-45260-6
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Résumé
Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that TLR4-induced responses are mediated by macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine. We also demonstrate that MIF regulates suboptimal TCR/CD3-mediated activation of T lymphocytes. On one hand, MIF prevents excessive TCR/CD3-mediated activation of CD4+ T lymphocytes under suboptimal stimulation conditions and, on the other hand, MIF enables activated CD4+ T lymphocytes to sense their microenvironment and adapt their effector response through TLR4. Therefore, MIF appears to be a major regulator of the activation of CD4+ T lymphocytes and the intensity of their effector response. TLR4-mediated activation is thus an important process for T cell-mediated immunity.