Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.

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Date

11 août 2014

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Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/srep05865

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25109392

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2045-2322

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A417AA7476AB1

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Animals; Asthma/immunology; Asthma/metabolism; Asthma/pathology; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; Cell Differentiation; Cell Proliferation; Cytokines/metabolism; Disease Models, Animal; Interleukin-17/genetics; Interleukin-17/metabolism; Interleukin-17/pharmacology; Lung/metabolism; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin/immunology; Phenotype; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Recombinant Proteins/pharmacology; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins/metabolism; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/metabolism; TYK2 Kinase/genetics; TYK2 Kinase/metabolism; Th17 Cells/cytology; Th17 Cells/immunology; Th17 Cells/metabolism; Th2 Cells/cytology; Th2 Cells/immunology; Th2 Cells/metabolism

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Mouse House mice Mus musculus House mouse

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C. Übel et al., « Role of Tyk-2 in Th9 and Th17 cells in allergic asthma. », Serveur académique Lausannois, ID : 10.1038/srep05865

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In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increased Th9 cells expressing IL-9 and IL-10 as well as T helper cells expressing IL-6, IL-10 and IL-21 with a defect in IL-17A and IL-17F production. This T helper phenotype was accompanied by increased SOCS3 in the lung of Tyk-2 deficient asthmatic mice. Finally, in vivo treatment with rIL-17A inhibited local CD4(+)CD25(+)Foxp3(+) T regulatory cells as well as Th2 cytokines without affecting IL-9 in the lung. These results suggest a role of Tyk-2 in different subsets of T helper cells mediated by SOCS3 regulation that is relevant for the treatment of asthma, cancer and autoimmune diseases.

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