CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.
Fiche du document
- doi: 10.1038/tpj.2015.82
- issn: 1470-269X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/tpj.2015.82
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/26644205
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1473-1150
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_342B86B6E9885
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Dysmetabolic syndrome X Metabolic cardiovascular syndrome Metabolic syndrome X Cardiovascular syndrome, Metabolic Insulin resistance syndromeCiter ce document
L. Quteineh et al., « CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation. », Serveur académique Lausannois, ID : 10.1038/tpj.2015.82
Métriques
Partage / Export
Résumé
Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a discovery sample of SOT recipients (n1=197). Positive results were tested for replication in two samples from the Swiss Transplant Cohort Study (STCS, n2=1294 and n3=759). Obesity and other metabolic traits were also tested. Associations with metabolic traits in population-based samples (n4=46'186, n5=123'865, n6>100,000) were finally analyzed. In the discovery sample, CRTC2 rs8450-AA genotype was associated with NODAT, fasting blood glucose and body mass index (PcorrectedA was significantly associated with several metabolic abnormalities. CRTC2 rs8450G>A appears to have an important role in the high prevalence of metabolic traits observed in patients with SOT. A weak association with metabolic traits was also observed in the population-based samples.