Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.

Fiche du document

Auteurs
Date

2009

Type de document
Périmètre
Langue
Identifiant
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.200809028

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/19307598

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/1540-8140[electronic]

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B7E22B892AE66

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Autocrine Communication; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines/metabolism; Epithelial Cells/enzymology; Epithelial Cells/immunology; Fibroblasts/enzymology; Fibroblasts/immunology; Gene Knockdown Techniques; Homeostasis; Humans; Intercellular Signaling Peptides and Proteins/metabolism; Interleukin 1 Receptor Antagonist Protein/genetics; Interleukin 1 Receptor Antagonist Protein/metabolism; Interleukin-1/genetics; Interleukin-1/metabolism; Interleukin-1alpha/metabolism; Interleukin-1beta/metabolism; MAP Kinase Kinase Kinases/metabolism; Mice; Mice, Knockout; Organ Culture Techniques; PPAR delta/deficiency; PPAR delta/genetics; PPAR-beta/deficiency; PPAR-beta/genetics; Paracrine Communication; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Skin/enzymology; Skin/immunology; Time Factors; Transcription Factor AP-1/metabolism; Transcriptional Activation; Wound Healing

Sujets proches En

Wound repair Healing of wounds Integument (Skin) Cutis Fibrocytes Desmocytes

Citer ce document

H.C. Chong et al., « Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. », Serveur académique Lausannois, ID : 10.1083/jcb.200809028

Métriques

Partage / Export

Résumé 0

Skin morphogenesis, maintenance, and healing after wounding require complex epithelial-mesenchymal interactions. In this study, we show that for skin homeostasis, interleukin-1 (IL-1) produced by keratinocytes activates peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) expression in underlying fibroblasts, which in turn inhibits the mitotic activity of keratinocytes via inhibition of the IL-1 signaling pathway. In fact, PPARbeta/delta stimulates production of the secreted IL-1 receptor antagonist, which leads to an autocrine decrease in IL-1 signaling pathways and consequently decreases production of secreted mitogenic factors by the fibroblasts. This fibroblast PPARbeta/delta regulation of the IL-1 signaling is required for proper wound healing and can regulate tumor as well as normal human keratinocyte cell proliferation. Together, these findings provide evidence for a novel homeostatic control of keratinocyte proliferation and differentiation mediated via PPARbeta/delta regulation in dermal fibroblasts of IL-1 signaling. Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner.

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets

Exporter en