FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.

Metadatas

Date

2009

type
Language
Identifiers
Relations

This document is linked to :
info:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.200901104

This document is linked to :
info:eu-repo/semantics/altIdentifier/pmid/19398761

This document is linked to :
info:eu-repo/semantics/altIdentifier/eissn/1540-8140

This document is linked to :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_15652A41591D3

Licenses

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer




Cite this document

C. Norrmén et al., « FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. », Serveur académique Lausannois, ID : 10.1083/jcb.200901104


Metrics


Share / Export

Abstract 0

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide a molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process. We further identify transcription factor NFATc1 as a novel regulator of lymphatic development and describe a previously unsuspected link between NFATc1 and Foxc2 in the regulation of lymphatic maturation. We also provide a genome-wide map of FOXC2-binding sites in lymphatic endothelial cells, identify a novel consensus FOXC2 sequence, and show that NFATc1 physically interacts with FOXC2-binding enhancers. As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention.

document thumbnail

From the same authors

On the same subjects

Export in