A new life for an old pump: V-ATPase and neurotransmitter release.

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2014

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info:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.201403040

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info:eu-repo/semantics/altIdentifier/eissn/1540-8140

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_24C475F2A7132

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S. Vavassori et al., « A new life for an old pump: V-ATPase and neurotransmitter release. », Serveur académique Lausannois, ID : 10.1083/jcb.201403040


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Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.

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