An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7).

Fiche du document

Auteurs
Date

1992

Type de document
Périmètre
Langue
Identifiants
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.175.6.1623

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/1316932

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0022-1007

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_34B1C10DA8A97

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , CC BY-NC-SA 4.0 , https://creativecommons.org/licenses/by-nc-sa/4.0/

Mots-clés 0

Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Cloning, Molecular; Female; Genes, Viral; Lymph Nodes/immunology; Mammary Tumor Virus, Mouse/genetics; Mammary Tumor Virus, Mouse/isolation & purification; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; Milk/microbiology; Minor Lymphocyte Stimulatory Antigens/analysis; Minor Lymphocyte Stimulatory Antigens/genetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction/methods; Receptors, Antigen, T-Cell/genetics; Sequence Homology, Nucleic Acid; Species Specificity; T-Lymphocytes/immunology; Thymus Gland/immunology

Sujets proches En

Mouse House mice Mus musculus House mouse

Citer ce document

W. Held et al., « An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). », Serveur académique Lausannois, ID : 10.1084/jem.175.6.1623

Métriques

Partage / Export

Résumé 0

The classical minor lymphocyte stimulating (Mls) antigens, which induce a strong primary T cell response in vitro, are closely linked to endogenous copies of mouse mammary tumor viruses (MMTV). Expression of Mls genes leads to clonal deletion of T cell subsets expressing specific T cell receptor (TCR) V beta chains. We describe the isolation and characterization of a new exogenous (infectious) MMTV with biological properties similar to the Mls antigen Mls-1a. In vivo administration of either Mls-1a-expressing B cells or the infectious MMTV (SW) led to an increase of T cells expressing V beta 6 followed by their deletion. Surprisingly, different kinetics of deletion were observed with the exogenous virus depending upon the route of infection. Infection through the mucosa led to a slow deletion of V beta 6+ T cells, whereas deletion was rapid after subcutaneous infection. Sequence analysis of the open reading frames in the 3' long terminal repeat of both this exogenous MMTV (SW) and of Mtv-7 (which is closely linked to Mls-1a) revealed striking similarities, particularly in the COOH terminus, which has been implicated in TCR V beta recognition. The identification of an infectious MMTV with the properties of a strong Mls antigen provides a new, powerful tool to study immunity and tolerance in vivo.

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets

Exporter en