T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.
Fiche du document
1998
- doi: 10.1084/jem.187.8.1193
- issn: 0022-1007
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.187.8.1193
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/9547331
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0022-1007
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9ACADD245FD79
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Plasmocytes Plasmacytes Mouse House mice Mus musculus House mouse Immunisation Intercellular communication Cellular interaction Cell-cell interaction Cell communication Cellular communication (Biology) B lymphocytes Bursa equivalent cells Bone marrow derived cellsCiter ce document
K.M. Toellner et al., « T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. », Serveur académique Lausannois, ID : 10.1084/jem.187.8.1193
Métriques
Partage / Export
Résumé
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cgamma2a and Cgamma1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten-protein can proceed in a node where there is substantial Th1 activity.