Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.

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Auteurs
Date

1999

Type de document
Périmètre
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Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.190.11.1697

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/10587360

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0022-1007

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DBCE912552875

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Animals; Antibodies, Antinuclear/blood; Autoantibodies/blood; Autoimmune Diseases/genetics; Autoimmune Diseases/immunology; B-Cell Activating Factor; B-Lymphocytes/immunology; Flow Cytometry; Humans; Immunoglobulin A/blood; Immunoglobulin G/blood; Immunoglobulin M/blood; Immunoglobulins/metabolism; Kidney/immunology; Kidney/pathology; Kinetics; Leukocyte Count; Lung/immunology; Lymphatic Diseases/genetics; Lymphatic Diseases/immunology; Membrane Proteins/genetics; Membrane Proteins/immunology; Mice; Mice, Transgenic; Reverse Transcriptase Polymerase Chain Reaction; Rheumatoid Factor/blood; T-Lymphocytes/immunology; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/immunology

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Mouse House mice Mus musculus House mouse

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F. Mackay et al., « Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. », Serveur académique Lausannois, ID : 10.1084/jem.190.11.1697

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The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti-DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.

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