In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.
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1999
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info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.190.6.775
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info:eu-repo/semantics/altIdentifier/pmid/10499916
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info:eu-repo/semantics/altIdentifier/pissn/0022-1007
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CDA12DB53A1D2
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Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cellsCiter ce document
D.E. Speiser et al., « In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. », Serveur académique Lausannois, ID : 10.1084/jem.190.6.775
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Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.